A woman pinching her brows at her desk, teal cup in hand — that still, waiting moment of a migraine building. For up to 75% of perimenopausal women, this gets worse during the hormonal transition. The reason is specific: estrogen regulates CGRP, the primary pain-signalling molecule of the trigeminal nervous system. When it fluctuates, the threshold drops. Here's the science and what the 2026 evidence says actually helps.
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