The WHI study scared women off HRT for twenty years. In November 2025, the FDA initiated the removal of its broad boxed warnings with revised labelling in force from February 2026. A large observational study of 120 million patient records found approximately 60% lower odds of breast cancer, heart attack, and stroke for perimenopausal estrogen users. The evidence has shifted significantly. Here is what it actually says the benefits, the real risks and the formulation distinc