Perimenopause rage is neurological, not personal. Estrogen volatility disrupts the amygdala–prefrontal cortex circuit governing impulse control, while declining progesterone removes the brain's GABA-A calming buffer. This article covers the 2025 Menopause Society research on hormonal anger and which interventions — HRT, CBT, sleep, exercise — have the strongest evidence.

Women are 40% more likely to develop depression during perimenopause — even with no prior mental health history. Estrogen withdrawal disrupts serotonin, dopamine, and GABA simultaneously: the three systems your brain relied on for emotional stability your entire adult life. Anxiety, rage, grey heaviness, and 3am dread are not a breakdown. They are neuroscience. Here's the hormonal mechanism, the window of vulnerability science, and the evidence-based protocol that actually he