Perimenopause rage is neurological, not personal. Estrogen volatility disrupts the amygdala–prefrontal cortex circuit governing impulse control, while declining progesterone removes the brain's GABA-A calming buffer. This article covers the 2025 Menopause Society research on hormonal anger and which interventions — HRT, CBT, sleep, exercise — have the strongest evidence.

A 43-year-old entrepreneur shares what she learned about the estrogen-serotonin link in perimenopause — and the natural supplements and lifestyle habits (omega-3, magnesium, ashwagandha, vitamin D, fermented foods) she uses to support mood before reaching for medication. Research-backed, honest, and written for real women navigating hormonal change.