If you're suddenly reacting to wine, aged cheese, or foods you've eaten for years without issue, your hormones may have changed the rules. Perimenopause causes estrogen to spike erratically, which activates mast cells and suppresses the DAO enzyme your body uses to clear histamine. The result: histamine builds up, and foods that were once fine aren't anymore. This isn't a new allergy — it's a hormonal disruption to your histamine metabolism, and it's more common than most doc